TABLE 2.

Interactions Among Selected FKBP5 Single-Nucleotide Polymorphisms (SNPs), Prebaseline Adverse Life Events, and the Risk of the First Occurrence of a Major Depressive Episode in 884 Young Community Subjects in a 10-Year Prospective Study

	Additive Interaction Effect Between Prebaseline Adverse Life Event and Homozygosity for SNP Minor Allele on Incident Major Depressive Episode During Follow-Upb
	Homozygous for Minor Allele Versus Heterozygous			Homozygous for Minor Allele Versus Homozygous for Major Allele
SNPa and Presence of Lifetime Adverse Event Preceding Baseline	Risk Difference in Percentage Pointsc	95% CI	p	Risk Difference in Percentage Pointsc	95% CI	p
rs3800373 (CC/AC/AA)
Any adverse life event	13.0d	3.2 to 22.7	0.009	7.0	–7.6 to 21.6	0.35
Any separation event	11.0d	0.0 to 22.0	0.05	3.7	–13.0 to 20.4	0.67
Any trauma	15.3d,e,f	9.0 to 21.6	<0.001	15.2d,e,f	8.0 to 22.3	<0.001
Any severe trauma	16.7d,e,f	12.0 to 21.4	<0.001	16.1d,e,f	10.1 to 22.1	<0.001
rs9296158 (AA/AG/GG)
Any adverse life event	13.0d	3.7 to 22.4	0.006	6.4	–7.9 to 20.6	0.39
Any separation event	12.2d	2.9 to 21.6	0.01	2.2	–14.4 to 18.7	0.80
Any trauma	12.3d	3.5 to 21.2	0.006	14.0d,e,f	6.4 to 21.7	<0.001
Any severe trauma	13.3d,e	5.6 to 21.0	<0.001	14.4d,e,f	7.3 to 21.4	<0.001
rs1360780 (TT/CT/CC)
Any adverse life event	12.7d	3.1 to 22.4	0.009	6.1	–8.2 to 20.5	0.40
Any separation event	11.6d	1.6 to 21.6	0.03	2.0	–14.6 to 18.6	0.82
Any trauma	12.7d,e	4.1 to 21.2	0.003	14.0d,e,f	6.4 to 21.6	<0.001
Any severe trauma	13.5d,e,f	5.9 to 21.0	<0.001	14.4d,e,f	7.5 to 21.3	<0.001
rs9470080 (TT/CT/CC)
Any adverse life event	11.6d	1.3 to 21.8	0.03	2.4	–13.6 to 18.3	0.78
Any separation event	9.4	–2.3 to 21.2	0.12	–3.4	–23.3 to 16.5	0.74
Any trauma	13.1d,e,f	5.2 to 21.0	0.001	13.2d,e,f	5.3 to 21.1	0.001
Any severe trauma	13.6d,e,f	6.7 to 20.8	<0.001	13.3d,e,f	5.7 to 20.9	<0.001
rs4713916 (AA/AG/GG)
Any adverse life event	18.0d,e,f	10.2 to 25.7	<0.001	15.2d	3.3 to 27.1	0.02
Any separation event	12.8d	3.0 to 22.6	0.01	5.6	–10.4 to 21.6	0.50
Any trauma	15.9d,e,f	10.6 to 21.2	<0.001	16.6d,e,f	11.3 to 21.9	<0.001
Any severe trauma	16.0d,e,f	11.5 to 20.6	<0.001	16.3d,e,f	11.5 to 21.2	<0.001

^aMinor allele is listed first, i.e., for rs3800373 the minor allele is C; for rs9296158 the minor allele is A; for rs1360780 the minor allele is T; for rs9470080 the minor allele is T; and for rs4713916 the minor allele is A.

^bA total of 159 individuals first met the DSM-IV criteria for a major depressive episode during follow-up. The reference group comprised the subjects without an incident major depressive episode during follow-up.

^cThe amount by which the sum of the independent effects of an adverse life event (in the absence of the risk genotype, i.e., homozygosity for the minor allele) and the risk genotype (in the absence of adverse life events) is exceeded by the joint effect of both factors, i.e., an adverse life event in the presence of the risk genotype.

^dSignificant risk difference (p<0.05) when controlled for age and gender.

^eSignificant risk difference (p<0.05) when controlled for age and gender and after Bonferroni correction for multiple testing (two independent event conditions, five SNPs).

^fSignificant risk difference (p<0.05) when controlled for age, gender, and baseline anxiety and substance use disorders and after Bonferroni correction for multiple testing (two independent event conditions, five SNPs).