Table 1.
Genes selected for knockout analysis
| Node Name | Gene or Metabolite |
|---|---|
| TRP |
Tryptophan |
| TPH 2 |
Tryptophan hydroxylase 2 |
| 5-HTP |
5-hydroxytryptophan |
| AADC |
Aromatic L-amino decarboxylase |
| 5-HT* |
Serotonin in the DRN |
| MAOA |
Monoamine-oxidase A |
| SL18A2 |
Solute carrier 18A-2 |
| 5-HT |
Synaptic serotonin |
| 5-HT1A |
Postsynaptic 5-HT receptor 1Aa |
| K-Channel |
Presynaptic potassium channel a |
| K+ |
Postsynaptic potassium |
| 5-HT1A* |
Presynaptic 5-HT receptor 1Aa |
| K-Channel* |
Presynaptic potassium channel a |
| K + * |
Presynaptic potassium |
| 5-HTT |
Serotonin transporter |
| CREB |
cAMP-response element binding |
| BDNF |
Brain-derived neurotrophic factor |
| TRkB |
Tyrosine kinase B |
| CRH |
Corticotropin releasing hormone |
| VPA |
Vasopressin |
| ACTH |
Adrenocorticotropic hormone |
| cortisol |
Cortisol |
| GR/MR(PG) |
Glucocorticoid/Mineralocorticoid receptor (pituitary gland)b |
| GR/MR(PVN) |
Glucocorticoid/Mineralocorticoid receptor (paraventricular nucleus)b |
| GR/MR(DRN) |
Glucocorticoid/Mineralocorticoid receptor (dorsal raphe nucleus)b |
| GR/MR(SSC) |
Glucocorticoid/Mineralocorticoid receptor (sensitive serotonin cell)b |
| NFkB | Nuclear factor |
a. Gene knocked out in a specific tissue, b. gene knocked out globally, * presynaptic node expressed in the dorsal raphe nucleus. (DRN) dorsal raphe nucleus, (PG) pituitary gland, (PVN) paraventricular nucleus, (SSC) sensitive serotonin cell.