Table 1.
The RAD50 and MRE11 gene variants detected in laryngeal cancer (LC), multiple primary tumors with laryngeal cancer (MPT-LC), multiple primary tumors of head and neck (MPT) and controls
| Gene | Exon/intron | Nucleotide change | Aminoacid change |
LC n = 175 OR (95% CI) |
MPT-LC n = 115 OR (95% CI) |
MPT n = 68 OR (95% CI) |
Controls n = 506 |
|---|---|---|---|---|---|---|---|
|
RAD50 |
Ex. 4 |
c.379G>A |
p.V127I |
2 |
- |
- |
2 |
| 2.91 (0.41-20.85) | |||||||
| |
Ex. 7 |
c.943G>T |
p.V315L |
- |
2 |
- |
1 |
| 8.96 (0.81-99.68) | |||||||
| |
Ex. 25 |
c.3876C>T |
- |
1 |
- |
- |
0/180 |
| 8.71 (0.35-215) | |||||||
|
MRE11 |
Int. 16 |
c.1783-86delAG |
- |
39 |
18 |
20 |
61/279 |
| 1.03 (0.65-1.62) | 0.66 (0.37-1.18) | 1.49 (0.82-2.69) |