Table 5B.
SNPs associated with cognitive performance T-scores controlling for substance dependence: African-American population
| Domain | N (No SUD/SUD) | Gene | SNP | β_No SUD | β_SUD | P |
|---|---|---|---|---|---|---|
| Global | 135 (23/112) | N/A | ||||
| Motor | 128 (23/105) | DRD1 | rs265973 | 10.51 | 2.186 | 0.022 |
| DRD1 | rs686 | −5.777 | 1.665 | 0.010 | ||
| DRD2 | rs12365283 | 23.59 | −1.815 | 0.007 | ||
|
| ||||||
| Processing Speed | 131 (23/108) | DRD1 | rs4532 | −3.124 | 2.917 | 0.038 |
|
| ||||||
| Working Memory | 132 (23/109) | DRD1 | rs265973 | −5.221 | 2.996 | 0.042 |
|
| ||||||
| Executive Functioning | 129 (22/107) | N/A | ||||
|
| ||||||
| Learning | 135 (23/112) | N/A | ||||
|
| ||||||
| Memory | 135 (23/112) | DRD2 | rs2283265* | −10.91 | 0.0869 | 0.039 |
| DRD2 | rs1076560* | −10.91 | 0.0869 | 0.039 | ||
|
| ||||||
| Verbal Fluency | 132 (20/112) | N/A | ||||
DRD2 SNPS rs2283265/rs1076560 form a haploblock within the AA subset, which accounts for the identical β and P values observed.