Table 3.
Model-based odds ratios and 95% confidence intervalsa of endometrial cancer risk associated with obesity-related measures and history of diabetes mellitus
| Category a | Middle point b | All women
|
Premenopausal women
|
Postmenopausal women
|
|||
|---|---|---|---|---|---|---|---|
| Numberc | OR(95% CI)d | Numberc | OR(95% CI)d | Numberc | OR(95% CI)d | ||
| WHR | |||||||
| ≤0.774 | 0.750 | 92/206 | 0.7(0.6–0.9) | 31/103 | 0.4(0.3–0.6) | 61/103 | 1.0(0.8–1.3) |
| 0.775–0.803 | 0.791 | 144/207 | 0.8(0.8–0.9) | 78/97 | 0.7(0.6–0.8) | 66/110 | 0.9(0.8–1.0) |
| 0.804–0.830 | 0.814 | 200/207 | 1.0 | 88/75 | 1.0 | 112/132 | 1.0 |
| 0.831–0.864 | 0.845 | 270/207 | 1.4(1.2–1.6) | 125/72 | 1.4(1.1–1.8) | 145/135 | 1.3(1.1–1.6) |
| >0.864 | 0.886 | 338/206 | 1.6(1.3–2.0) | 132/48 | 1.8(1.3–2.6) | 206/158 | 1.5(1.1–2.0) |
| Interaction test | p<0.001 | ||||||
| Waist circumference(cm) | |||||||
| ≤71 | 67 | 71/208 | 0.5(0.3–0.6) | 33/114 | 0.2(0.1–0.4) | 38/94 | 0.8(0.5–1.2) |
| 72–76 | 73 | 141/232 | 0.7(0.6–0.8) | 69/112 | 0.5(0.4–0.6) | 72/120 | 0.8(0.7–1.0) |
| 77–80 | 78 | 168/180 | 1.0 | 91/71 | 1.0 | 77/109 | 1.0 |
| 81–87 | 83 | 282/234 | 1.5(1.3–1.7) | 128/64 | 1.8(1.4–2.4) | 154/170 | 1.4(1.1–1.6) |
| >87 | 91 | 382/179 | 2.3(1.7–3.1) | 133/34 | 4.1(2.4–7.0) | 249/145 | 2.0(1.4–2.8) |
| Interaction test | p=0.002 | ||||||
| BMI | |||||||
| ≤20.92 | 19.64 | 104/207 | 1.1(0.9–1.5) | 50/99 | 1.3(0.9–1.9) | 54/108 | 1.1(0.8–1.6) |
| 20.93–22.68 | 21.85 | 128/205 | 1.0(0.9–1.1) | 64/92 | 1.1(0.9–1.3) | 64/113 | 1.0(0.9–1.1) |
| 22.69–24.32 | 23.44 | 190/208 | 1.0 | 92/87 | 1.0 | 98/121 | 1.0 |
| 24.33–26.47 | 25.33 | 214/206 | 1.0(0.9–1.2) | 92/63 | 0.9(0.7–1.2) | 122/143 | 1.1(0.9–1.3) |
| >26.47 | 28.44 | 408/207 | 1.1(0.8–1.5) | 156/54 | 0.7(0.4–1.2) | 252/153 | 1.3(0.9–1.9) |
| Interaction test | p=0.184 | ||||||
| History of diabetes mellitus | |||||||
| No | 880/957 | 1.0 | 408/381 | 1.0 | 472/576 | 1.0 | |
| Yes | 156/71 | 1.9(1.4–2.6) | 45/12 | 1.6(0.8–3.3) | 111/59 | 2.0(1.4–2.8) | |
| Interaction test | p=0.986 | ||||||
WHR, waist circumference, and BMI were categorized by quintiles according to the values in control group.
The middle values in each quintile according to the distributions in control group.
Number of cases/controls in each quintile.
The odds ratios (OR) and 95% confidence intervals (CI) were estimated for the middle points of the first, second, fourth, and fifth quintiles of continuous obesity variables as compared with the middle point of the third quintile (the median) with model parameters derived from logistic regression models which included the restricted cubic spline function with 4 knots to account for non-linearity and were adjusted for age at menarche, menopausal status, total years of menstruation, oral contraceptive use, cancer history in first degree relatives, and BMI (for WHR and waist circumference) or waist circumference (for BMI and history of diabetes mellitus).