Table 4.
The effect of WHR, waist circumference, and a history of diabetes mellitus on endometrial cancer risk by genotypes of two CRP SNPs (rs1130864 and rs2794520)
| Categorya | rs1130864
|
rs2794520
|
||||||
|---|---|---|---|---|---|---|---|---|
| C/C
|
C/T & T/T
|
T/T
|
C/T & C/C
|
|||||
| Numberb | OR (95% CI)c | Numberb | OR (95% CI)c | Numberb | OR (95% CI)c | Numberb | OR (95% CI)c | |
| All women | ||||||||
| WHR | ||||||||
| ≤0.774 | 76/184 | 0.7(0.5–0.9) | 14/19 | 0.9(0.5–1.6) | 30/80 | 0.8(0.6–1.2) | 60/122 | 0.7(0.5–0.9) |
| 0.775–0.803 | 129/182 | 0.8(0.7–0.9) | 13/23 | 0.9(0.7–1.2) | 41/80 | 0.8(0.7–0.9) | 100/125 | 0.9(0.8–1.0) |
| 0.804–0.830 | 169/177 | 1.0 | 28/26 | 1.0 | 61/62 | 1.0 | 133/143 | 1.0 |
| 0.831–0.864 | 240/182 | 1.4(1.2–1.7) | 25/24 | 1.0(0.7–1.7) | 105/70 | 1.8(1.4–2.3) | 159/135 | 1.2(1.0–1.5) |
| >0.864 | 313/173 | 1.8(1.4–2.3) | 24/29 | 0.7(0.3–1.3) | 115/52 | 2.6(1.8–3.8) | 219/149 | 1.4(1.0–1.8) |
| Interaction test | p=0.013 | p=0.007 | ||||||
| Waist circumference (cm) | ||||||||
| ≤71 | 63/181 | 0.5(0.3–0.7) | 8/22 | 0.4(0.2–1.3) | 20/72 | 0.5(0.3–0.9) | 50/131 | 0.4(0.3–0.6) |
| 72–76 | 127/207 | 0.7(0.6–0.8) | 12/24 | 0.7(0.5–1.1) | 47/87 | 0.7(0.5–0.8) | 92/145 | 0.7(0.6–0.8) |
| 77–80 | 146/161 | 1.0 | 16/18 | 1.0 | 48/67 | 1.0 | 112/110 | 1.0 |
| 81–87 | 248/201 | 1.5(1.3–1.8) | 32/30 | 1.1(0.7–1.8) | 94/74 | 1.9(1.4–2.5) | 184/158 | 1.3(1.1–1.6) |
| >87 | 343/148 | 2.8(2.0–3.8) | 36/27 | 0.9(0.4–2.3) | 143/44 | 4.6(2.7–8.0) | 233/130 | 1.8(1.3–2.6) |
| Interaction test | p=0.083 | p=0.002 | ||||||
| History of diabetes mellitus | ||||||||
| No | 779/840 | 1.0 | 88/104 | 1.0 | 299/325 | 1.0 | 564/620 | 1.0 |
| Yes | 140/54 | 2.2(1.5–3.1) | 16/16 | 0.9(0.4–2.0) | 49/18 | 2.1(1.1–3.9) | 103/50 | 1.8(1.2–2.7) |
| Interaction test | p=0.064 | p=0.387 | ||||||
| Premenopausal women | ||||||||
| WHR | ||||||||
| ≤0.774 | 26/90 | 0.4(0.3–0.7) | 3/12 | 0.2(0.1–1.1) | 10/44 | 0.4(0.2–0.8) | 20/57 | 0.4(0.2–0.7) |
| 0.775–0.803 | 69/86 | 0.7(0.6–0.8) | 8/9 | 0.6(0.4–1.0) | 20/34 | 0.7(0.5–0.8) | 56/62 | 0.8(0.7–0.9) |
| 0.804–0.830 | 73/64 | 1.0 | 13/10 | 1.0 | 31/22 | 1.0 | 56/52 | 1.0 |
| 0.831–0.864 | 108/63 | 1.5(1.2–2.0) | 13/8 | 0.9(0.3–2.2) | 45/27 | 2.0(1.3–3.1) | 75/45 | 1.2(0.9–1.6) |
| >0.864 | 125/35 | 2.4(1.6–3.6) | 6/11 | 0.4(0.1–1.8) | 47/14 | 3.2(1.7–6.0) | 84/34 | 1.3(0.9–2.1) |
| Interaction test | p<0.001 | p=0.176 | ||||||
| Waist circumference (cm) | ||||||||
| ≤71 | 30/99 | 0.2(0.1–0.4) | 3/13 | 0.2(0.0–1.4) | 9/39 | 0.2(0.1–0.4) | 23/72 | 0.3(0.2–0.5) |
| 72–76 | 61/100 | 0.5(0.4–0.6) | 6/11 | 0.7(0.3–1.3) | 22/39 | 0.4(0.3–0.5) | 45/73 | 0.6(0.5–0.7) |
| 77–80 | 77/64 | 1.0 | 10/7 | 1.0 | 24/30 | 1.0 | 64/41 | 1.0 |
| 81–87 | 111/51 | 2.1(1.6–2.9) | 15/11 | 0.7(0.3–1.9) | 47/20 | 3.1(1.9–5.0) | 79/43 | 1.4(1.0–2.0) |
| >87 | 123/24 | 6.9(3.8–12.6) | 9/8 | 0.4(0.1–2.3) | 51/13 | 12.1(4.5–32.6) | 80/21 | 2.6(1.4–4.9) |
| Interaction test | p=0.002 | p=0.287 | ||||||
| History of diabetes mellitus | ||||||||
| No | 360/328 | 1.0 | 39/46 | 1.0 | 141/134 | 1.0 | 258/240 | 1.0 |
| Yes | 41/8 | 2.0(0.9–4.6) | 4/4 | 0.7(0.1–3.3) | 12/4 | 1.7(0.3–4.1) | 32/8 | 1.8(0.8–4.3) |
| Interaction test | p=0.218 | p=0.589 | ||||||
| Postmenopausal women | ||||||||
| WHR | ||||||||
| ≤0.774 | 49/94 | 0.9(0.7–1.2) | 11/7 | 1.9(0.7–4.9) | 20/36 | 1.2(0.7–2.1) | 40/65 | 0.9(0.7–1.3) |
| 0.775–0.803 | 60/96 | 0.9(0.8–1.0) | 5/14 | 1.1(0.8–1.5) | 21/46 | 0.9(0.8–1.1) | 44/63 | 0.9(0.8–1.0) |
| 0.804–0.830 | 96/113 | 1.0 | 15/16 | 1.0 | 30/40 | 1.0 | 77/91 | 1.0 |
| 0.831–0.864 | 132/119 | 1.3(1.1–1.6) | 12/16 | 1.1(0.6–2.2) | 60/43 | 1.5(1.1–2.1) | 84/90 | 1.3(1.0–1.6) |
| >0.864 | 188/138 | 1.5(1.1–2.0) | 18/18 | 1.2(0.5–2.9) | 68/38 | 2.1(1.3–3.5) | 135/115 | 1.3(1.0–1.9) |
| Interaction test | p=0.360 | p=0.130 | ||||||
| Waist circumference (cm) | ||||||||
| ≤71 | 33/82 | 0.8(0.5–1.2) | 5/9 | 1.0(0.2–4.4) | 11/33 | 1.2(0.6–2.7) | 27/59 | 0.7(0.4–1.1) |
| 72–76 | 66/107 | 0.8(0.7–1.0) | 6/13 | 0.9(0.5–1.4) | 25/48 | 0.9(0.7–1.2) | 47/72 | 0.8(0.7–1.0) |
| 77–80 | 69/97 | 1.0 | 6/11 | 1.0 | 24/37 | 1.0 | 48/69 | 1.0 |
| 81–87 | 137/150 | 1.3(1.1–1.6) | 17/19 | 1.5(0.8–2.8) | 47/54 | 1.6(1.1–2.4) | 105/115 | 1.2(1.0–1.5) |
| >87 | 220/124 | 2.0(1.3–2.9) | 27/19 | 1.9(0.6–6.2) | 92/31 | 3.3(1.7–6.7) | 153/109 | 1.6(1.0–2.5) |
| Interaction test | p=0.823 | p=0.147 | ||||||
| History of diabetes mellitus | ||||||||
| No | 419/512 | 1.0 | 49/58 | 1.0 | 158/188 | 1.0 | 306/380 | 1.0 |
| Yes | 99/46 | 2.2(1.5–3.3) | 12/12 | 1.1(0.4–2.9) | 37/14 | 2.9(1.4–6.1) | 71/42 | 1.8(1.1–2.7) |
| Interaction test | p=0.144 | p=0.198 | ||||||