Table 3.
Substrate scope for the asymmetric reaction.a
| entry | substrate | product | yield (%) | er |
|---|---|---|---|---|
| 1 |
 29 |
 30 |
78 | 87.5:12.5 |
| 2 |
 6 |
 (S)-7 |
90 | 86:14 |
| 3 |
 31 |
 32 |
77 | 82:18 |
| 4 |
 33 |
 34 |
72 | 84:16 |
| 5 |
 35 |
 36 |
84 | 83:17 |
| 6 |
 12 |
 (S)-13 |
71 | 83:17 |
| 7 |
 37 |
 38 |
88 | 84.5:15.5 |
| 8 |
 39 |
 40 |
74 | 80.5:19.5 |
| 9 |
 41 |
 (S)-17 |
86 | 74:26 |
| 10 |
 16 |
 (S)-17 |
13 | 74:26 |
| 11 |
 42 |
 43 |
80 | dr = 28:1 |
| 12 |
 14 |
 44 |
81 | dr = 1.4:1 |
a
Please see the Supporting Information for precise experimental details.