Table 1. Demographic characteristics of essential tremor cases and controls.
ET | All controls (non-diseased controls and PSP) | Non-diseased controls | Diseased controls (PSP) | |
---|---|---|---|---|
N‡ | 35 | 32 | 21 | 11 |
Age (years) | 84.9±6.5 | 74.5±13.6† | 74.9±16.2* | 73.7±7.1† |
Female gender | 22 (62.9) | 11 (35.5)* | 7 (33.3)* | 4 (36.4) |
Brain weight (g) | 1205±146 | 1245±176 | 1301±178* | 1137±117* |
Postmortem interval (h) | 5.9±3.0 | 8.5±7.9 | 8.7±8.4 | 8.2±7.5 |
Braak AD stage | 2.1±1.1 | 1.0±1.3† | 0.8±1.4† | 1.3±0.9† |
CERAD plaque score§ | 0.9±1.1 | 0.4±0.7 | 0.4±0.8 | 0.4±0.7 |
PC count | 35.1±11.7 | 43.2±17.8* | 47.9±17.9† | 32.3±12.2 |
HPCs | 3.8±3.6, 3 (0–14) | 1.6±1.7, 1 (0–5)† | 1.9±1.8, 1 (0–5)* | 1.1±1.2, 1 (0–4)* |
Mean±SD and frequency (%) are reported.
p <0.05.
p <0.01, comparing each group to ET cases.
Four outliers were excluded.
CERAD plaque scores were converted from letters to numbers: 0 indicates absent; 1, sparse; 2, moderate; and 3, severe.
AD, Alzheimer's disease; CERAD, Consortium to Establish a Registry for AD; ET, essential tremor; HPC, heterotopic Purkinje cell; PC, Purkinje cell; PSP, progressive supranuclear palsy.