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. Author manuscript; available in PMC: 2014 Apr 16.
Published in final edited form as: Curr Opin Virol. 2013 Apr 16;3(2):10.1016/j.coviro.2013.03.013. doi: 10.1016/j.coviro.2013.03.013

Figure 4. Comparison of NS5B structures.

Figure 4

(A) Three NS5B crystal structures are aligned, and conformational differences can be seen in the fingers and thumb domains (PDB: 1YUY, 1YV2 and 3I5K). The GDD motif, β-flap, and C-terminal linker are colored cyan, red and blue respectively. The template channel is noted. (B) and (C) Structural comparison of nucleotides coordinated in catalytic pockets (PDB: 2XI3 and 1GX6 for GTP and UTP soaked complexes respectively). The proteins are shown as ribbon and stick models, and colored yellow. The nucleotides are shown as sticks and spheres, and colored by elements. Metal ions are green spheres. TP stands for triphosphate. The α-, β-, and γ-phosphate groups are labeled for the complete nucleotides. The dashed lines represent possible atomic interactions.