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. Author manuscript; available in PMC: 2013 Dec 9.
Published in final edited form as: Mol Cell Endocrinol. 2008 Oct 21;299(1):10.1016/j.mce.2008.10.014. doi: 10.1016/j.mce.2008.10.014

Table 1.

Summary of endocrine changes with calorie restriction in humans; a comparison across previously published studies.

Variable CALERIE Biosphere 2 CRONIES
DHEA-S ↔ ↔
GH ↔ ↔
IGF-1 ↔ ↔
Insulin ↓ ↓ ↓
T3 ↓ ↓ ↓
T4 ↓ ↔ ↔

DHEA-S = dehydroepiandrosterone sulfate, GH = growth hormone, IGF-1 = insulin-like growth factor 1, T3 = triiodothyronine, T4 = thyroxine, ↓ = decreased by calorie restriction, ↑ = increased by calorie restriction, ↔ = not changed by calorie restriction.