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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: J Mol Cell Cardiol. 2013 Sep 6;64:10.1016/j.yjmcc.2013.08.010. doi: 10.1016/j.yjmcc.2013.08.010

Fig.3. sAP-clamp Sequential Dissection of INaL and three major K+ currents from the same cell.

Fig.3

Representative traces of INaL, IKs, IKr and IK1 recorded from control cells (Panel A, n=6cells/5animals) and following facilitation by 10 nM ATX-II treatment (Panel B, n=5cells/3animals). ATX increased the peak current density (Panel C) and net charge (Panel D) without altering the K+ currents. Facilitation with ATX-II did not alter the dynamic I-V relationship (Panel E). When AP was lengthened the net charge carried by the current was increased as is shown by the good correlation with APD90 (Panel F).