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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: J Mol Cell Cardiol. 2013 Sep 6;64:10.1016/j.yjmcc.2013.08.010. doi: 10.1016/j.yjmcc.2013.08.010

Fig.4. Effect of INa,L on AP morphology.

Fig.4

Panel A shows representative APs recorded in the presence of different ATX-II concentrations. Using ATX-II to upregulate INaL resulted in AP lengthening and generation of EAD. Panel B shows the concentration dependent AP lengthening effect of ATX-II at 0.2 Hz stimulation rate (n=6–11cells/6 animals). Panel C show the induction of various forms of arrhythmogenic APs (EAD, DAD, TAP) with ATX-II 100 nM in the same cell.