Fig. 2.

Caspase-2 deficiency accelerates lymphomagenesis in Atm^−/− mice. (A) Kaplan–Meier plot comparing percentage tumor-free survival in cohorts of Atm^−/− (n = 38) and Atm^−/−Casp2^−/− (n = 22) mice (P = 0.0077, log rank test). (B) Comparison of tumor types, incidence, and onset. (C) Representative images of Atm^−/− and Atm^−/−Casp2^−/− thymic lymphomas and H&E-stained thymic lymphoma sections (magnification of 40×) showing tumor cell morphology. (Scale bar: 50 µm.) No spontaneous tumor development was observed in WT or Casp2^−/− mice over a 1-y period in the same pathogen-free animal facility.