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. 2013 Dec 9;4:433. doi: 10.3389/fimmu.2013.00433

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Copyright © 2013 Teijeira, Rouzaut and Melero.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Artistic representation of novel steps in DC migration into LVs under inflammatory conditions. (1) DC (Yellow) are attracted by CCL21 interstitial gradient and other chemokines toward LVs lined by specialized endothelial cells (red). (2) DCs dock to CCL21 (blue) adsorbed as enriched patches prior to adhesion and intravasation. (3) DCs adhere to LEC surface and get entrapped by ICAM-1 enriched microvilli projections(Orange). (4) DC intravasate in a LV accompanied by ICAM-1 enriched microvilli projections. (5) DC actively crawl inside the LV.