Table 1. Body and cardiac parameters derived from 16 week old mice used for Langendorff preparations.
WT (n=7) | R6/2 (n=7) | |
---|---|---|
Body weight (g) | 30.67 ± 0.63 | 23.58 ± 0.91 * |
Crown-rump length (cm) | 7.35 ± 0.09 | 7.11 ± 0.15 |
Ponderal index (kg/m3) | 77.26 ± 2.59 | 66.29 ± 3.70 * |
Heart weight whole, absolute (g) | 0.14 ± 0.01 | 0.10 ± 0.01 * |
whole, relative (% total) | 0.47 ± 0.02 | 0.45 ± 0.02 |
LV + septum, absolute (g) | 0.10 ± 0.003 | 0.07 ± 0.004 * |
LV + septum, relative (%total) | 69.79 ± 1.96 | 71.08 ± 2.27 |
RV, absolute (g) | 0.03 ± 0.005 | 0.02 ± 0.002 * |
RV, relative (% total) | 20.37 ± 2.87 | 19.03 ± 2.18 |
Heart rate (beats/min) | 338.0 ± 6.20 | 318.00 ± 10.80 |
Coronary flow rate (ml/min) | 2.21 ± 0.13 | 1.45 ± 0.18 * |
LV, left ventricle; RV, right ventricle. Data are means ± SEM. Significant differences are R6/2 compared to WT mice.
p<0.05