Table 2. Cardiac parameters derived from mice used for MRI scans.

	Scan 1 (13 weeks)		Scan 2 (16 weeks)
	WT (n=10)	R6/2 (n=9)	WT (n=10)	R6/2 (n=9)
Age (weeks)	13.1 ± 0.2	13.3 ± 0.1	16.7 ± 0.1	16.4 ± 0.1
Body weight (g)	27.7 ± 1.0	21.1 ± 1.4 **	29.3 ± 1.3	19.0 ± 1.1 ***
EDV (μl)	45.3 ± 1.5	37.3 ± 1.6 **	46.0 ± 1.4	29.1 ± 1.5 ***
ESV (μl)	20.9 ± 1.7	15.0 ± 1.4 *	18.2 ± 1.4	8.6 ±1.1 ***
SV (μl)	24.4 ± 1.0	22.3 ± 1.4	27.8 ± 1.2	20.6 ± 0.7 ***
CO (ml/min)	6.9 ± 0.5	6.1 ± 0.4	8.1 ± 0.5	5.5 ± 0.5 ***
EF (%)	54.0 ± 3.0	60.0 ± 3.0	61.0 ± 2.0	71.0 ± 2.0 **
LV bending angle (°)	13.3 ± 1.5	14.3 ± 1.5	11.0 ± 1.2	15.0 ± 1.4 *

EDV, end diastolic volume; ESV, end systolic volume; SV, stroke volume; CO, cardiac output; EF, ejection fraction; LV, left ventricle. Data are means ± SEM. Significant differences are R6/2 compared to WT mice.

^*p<0.05,

^**p<0.01,

^***p<0.001.