Table 1.
Method of Semiquantitative Histopathological Assessment
|
1. Tissue reaction scoring | |
|---|---|
| Tissue reaction element | Grading factor×weight factor=score |
| Width of inflammationa | 5 |
| Width of scara | 1 |
| Overall density of cellular reactionb | 5 |
| Number of cellsa | |
| Neutrophils | 6 |
| Lymphocytes | 2 |
| Plasma cells | 2 |
| Eosinophils | 1 |
| Macrophages | 1 |
| Giant cells | 1 |
| Fibroblasts | 1 |
| Total score | |
|
2. Tissue reaction grade | ||
|---|---|---|
| Total score | Tissue reaction grade | Designation |
| 1–10 | 1 | Minimal |
| 11–25 | 2 | Mild |
| 26–40 | 3 | Moderate |
| >40 | 4 | Severe |
| a. Width of inflammation or scar (diameter of response in μm) | No. cells (per 60×field) | Grade |
|---|---|---|
| 0 | 0 | 0 |
| 1–200 | 1–50 | 1 |
| 201–400 | 51–100 | 2 |
| 401–600 | 101–200 | 3 |
| >600 | >200 | 4 |
| b. Overall density of cellular reaction (assignment based on experience of pathologist) | |
|---|---|
| Bare scattering | 1 |
| 2 | |
| 3 | |
| Dense aggregation | 4 |