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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: J Pharm Sci. 2013 Oct 9;102(12):10.1002/jps.23738. doi: 10.1002/jps.23738

Figure 7. Radar chart analysis of protein aggregate and particle formation data from multiple analytical techniques to visualize the extent of IgG1 physical instability.

Figure 7

IgG1 mAb solutions containing 20 mM citrate phosphate buffer (pH 6.0) and varying NaCl concentrations were stressed by either heat at 65°C or stirring over time (n=3). Samples were evaluated by a combination of SEC, RMM and MFI. See methods section for experimental details of each accelerated stress study. The Y-axis represents the amount of time the samples was stressed (in minutes), the X-axis represents NaCl concentration, and each radar chart panel (left and right) denotes heating and stirring, respectively. Refer to Figure 6 for an explanation of units and scales used in the individual radar charts for each analytical method (SEC, RMM and MFI data).