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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Mol Cancer Ther. 2013 Feb 26;12(5):10.1158/1535-7163.MCT-12-1130. doi: 10.1158/1535-7163.MCT-12-1130

Fig. 3. GSH-stimulated hypoxic DNA Cleavage by RPCs.

Fig. 3

DNA cleavage assay showing conversion of supercoiled pUC18 plasmid DNA to circular DNA upon treatment with GSH and Δ-32+ or ΔΔ-44+ under aerobic and anaerobic (3 ppm O2) conditions (panel A) DNA cleavage of GSH and Δ-32+ under anaerobic conditions in the presence of DMSO (oxygen radical scavinger) and TEMPO (carbon or metal-based radical scavinger) (panel B). In each figure, the upper band is the circular (cleaved) plasmid and the lower band is the (uncleaved) supercoiled plasmid.