Table 2.

DTP COMPARE Analysis¹: Mechanism of Action of RPC Δ-3²⁺ (NSC 747949)

Class	Drug	Correlation
Antimitotic Agent	Paclitaxel	0.91
	Vincristine	0.55
	Echinomycin	0.49
RNA/DNA Antimetabolite	Pyrazofurin	0.67
	5-FUDR	0.53
	5-fluorouracil	0.53
	Ftoafur	0.52
	Thioguanine	0.41
Alkylating Agent	Cyclodisone	0.62
	Piperazine alkylator	0.57
	Mitomycin C	0.52
	Porfiromycin	0.51
	CCNU	0.50
	Cisplatin	0.47
	Chlorambucil	0.43
	Thio-tepa	0.43
	Tetraplatin	0.42
	Chlorozotocin	0.40
Topo II	"N, N-dibenzyldaunomycin”	0.52

¹The DTP Compare Analysis uses cytotoxicity data for the test-drug across the NCI-60 spectrum of cell lines to determine is a correlation coefficient of measurement of the similarity in cytotoxic mechanism between the test subject drug, and known cytotoxic drugs with known mechanisms of action. The correlation coefficient ranging from 0 to 1 reflects the degree of similarity. Thus the above findings indicate maximum similarity of mechanism to paclitaxel and significant similarity to several drugs across the antimetabolite and alkylating agent class.