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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Mol Cancer Ther. 2013 Feb 26;12(5):10.1158/1535-7163.MCT-12-1130. doi: 10.1158/1535-7163.MCT-12-1130

Table 3.

MTDs of Ru (II) polypyridyl complexes in C57 BL/6 mice

Complex (chloride salt) Abbr. Maximum Tolerable Dose
MTD µmol complex /kg mouse
(mg complex /kg mouse)
rac-[Ru(phen)3]2+ 12+ 9.1 (6.6)
rac-[(phen)2Ru(tatpp)]2+ 32+ 65 (67)
mix-[(phen)2Ru(tatpp)Ru(phen)2]4+ 44+ 43 (66)
ΔΔ-[(phen)2Ru(tatpp)Ru(phen)2]4+ ΔΔ-44+ 64 (100)
ΛΛ-[(phen)2Ru(tatpp)Ru(phen)2]4+ ΛΛ-44+ 43 (66)
ΔΛ-[(phen)2Ru(tatpp)Ru(phen)2]4+ ΔΛ-44+ 43 (66)
mix-[(phen)2Ru(tpphz)Ru(phen)2]4+ 24+ 2.5 (3.3)