The review in brief
Type of review	Narrative
Literature search	PubMed with following keywords: pediatric ME/CFS, therapy, management, diagnostic criteria
Purpose	The present article aims to review the existing literature on pediatric ME/CFS. Current research findings on epidemiology, diagnosis and prognosis, biological markers of the illness and treatments are presented. Findings indicate that adult and pediatric ME/CFS represent distinct entities, and are both poorly understood
Conclusions	A lack of rigorous prevalence studies in this area limits the validity of current prevalence estimates; a pediatric case definition has been demonstrated to accurately distinguish between children with ME/CFS and controls; prognosis for children with ME/CFS is poor, and while health may improve, returning to pre-morbid functioning is rare; evidence of HPA axis dysfunction in adults with ME/CFS may translate to pediatric populations; more research is needed on non-pharmacologic and pharmacologic interventions for pediatric patients with ME/CFS but pacing strategies may be promising for this patient population
Limitations	Pediatric ME/CFS is an under-researched and poorly understood illness. Thus, the present review paper is limited in scope as there is a dearth of information about the condition