FIG. 2.

Transplants of 500 islet equivalent (IEQ) C57BL/6J islets into diabetic C57BL/6J mouse recipients. (A) Time to reversal to normoglycemia and (B) average nonfasting blood glucose of recipients following transplantation of 500 IEQ into the epididymal fat pad either free (gray line; n=6), within a PDMS scaffold (black line; n=9), or within a PDMS scaffold coloaded with fibrin/PDGF-BB (dashed black line; n=9). Reversal is defined as two consecutive readings <200 mg/dL. Implants were explanted between 110 and 150 days, where prompt reversal to a diabetic state was observed for all animals. Error bars=standard deviation. No statistical difference in time to reversal was observed for any of the groups.