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. Author manuscript; available in PMC: 2014 Dec 19.
Published in final edited form as: Neuroscience. 2013 Sep 20;254:10.1016/j.neuroscience.2013.08.071. doi: 10.1016/j.neuroscience.2013.08.071

Figure 6. CRF-R1 mRNA expression.

Figure 6

CRF-R1 mRNA was quantified relative to placebo (A–C), and baseline (D and E). CRF-R1 mRNA expression was decreased after 3 hours of morphine exposure; no differences were seen at 72 hours of morphine exposure (A). No differences were seen in either withdrawal group (B). CRF-R1 mRNA expression was also decreased following seven days of abstinence (C). There were no differences in the morphine or placebo groups compared to baseline (D and E). Data indicate mean ± SEM. * P < 0.05 vs. placebo by Student’s t-test. Baseline data: BL (n=8); placebo: 3 H (n=5), 72 H (n=5), PWD (n=6), SWD (n=5), 7D (n=6), 7D+FS (n=6); morphine: 3 H (n=5), 72 H (n=6), PWD (n=7), SWD (n=5), 7D (n=5), 7D+FS (n=6).