Table 1.
Hemodynamic Parameters in Infarcted Untreated Rats (MI), FG-, SASG-, FG-VATS-, and SASG-VATS Treated Rats, 6 Weeks After Myocardial Injury
| MI (n=8) | FG (n=8) | SASG (n=8) | FG-VATS (n=7) | SASG-VATS (n=8) | |
|---|---|---|---|---|---|
| LVEDP (mmHg) | 5.65±1.75 | 4.17±0.58 | 2.56±0.84b | 4.84±2.98 | 3.20±0.79a |
| Mean pressure (mmHg) | 22.45±3.41 | 23.34±4.35 | 20.62±3.75 | 23.70±6.00 | 24.66±4.17 |
| Systolic duration (s) | 0.10±0.01 | 0.10±0.02 | 0.10±0.01 | 0.09±0.01 | 0.09±0.01 |
| Diastolic duration (s) | 0.16±0.04 | 0.15±0.04 | 0.17±0.07 | 0.13±0.02 | 0.13±0.02 |
| Cycle duration (s) | 0.26±0.04 | 0.25±0.06 | 0.27±0.07 | 0.22±0.02 | 0.23±0.02 |
| Heart rate (BPM) | 255.59±40.23 | 237.89±33.98 | 246.94±44.76 | 272.25±26.79 | 279.08±30.56 |
| Max dP/dt (mmHg/s) | 2867.53±618.84 | 2839.34±429.85 | 3244.06±228.33 | 2669.19±576.28 | 3781.15±867.58a,e |
| Min dP/dt (mmHg/s) | −2170.70±415.70 | −2014.07±465.05 | −2247.50±691.02 | −2006.76±668.16 | −2733.17±776.39 |
| Tau (ms) | 19.55±3.73 | 17.58±4.91 | 16.46±1.74 | 17.31±2.47 | 16.76±4.68 |
| Cardiac output (mL/min) | 19.15±5.10 | 25.09±2.79 | 35.56±10.18c,d | 26.30±3.77 | 35.07±7.94c |
| Stroke volume (mL/beat) | 0.08±0.03 | 0.11±0.02 | 0.14±0.04b,d | 0.10±0.01 | 0.13±0.03a |
Statistical significance is indicated as follows: aP<0.05 versus MI.
b
P<0.01 versus MI.
c
P<0.0001 versus MI.
d
P<0.05 versus FG.
e
P<0.05 versus FG-VATS.
VATS, video-assisted thoracoscopic surgery; LVEDP, left ventricular end-diastolic pressure; BPM, beats per minute; FG, fibrin graft; SASG, subamnion-cord-lining mesenchymal stem cells angiogenic spheroids-enriched grafts; FG-VATS, FG generated in situ via VATS; SASG-VATS, SASG generated in situ via VATS.