Table 1.
Clinical and Biochemical Parameters in Each Experimental Group
| NX | DN | DN+ASCs | |
|---|---|---|---|
| Body weight(g) | 656.4±64.0 | 360.6±57.9a | 381.4±57.6a |
| Kidney weight(g) | 2.7±0.2 | 4.5±1.3a | 3.4±0.8a,b |
| Kidney/body weight(%) | 0.4±0.1 | 1.1±0.4a | 0.9±0.2a,b |
| Serum albumin level (g/L) | 36.5±2.3 | 29.7±8.5a | 32.1±5.6 |
| Serum creatinine (μM) | 39.0±2.0 | 36.9±7.0 | 27.2±3.7a,b |
| Blood urea nitrogen (mM) | 7.4±0.6 | 13.5±3.2a | 8.2±1.4b |
| Creatinine clearance (mL/min) | 1.4±0.3 | 1.1±0.2a | 1.4±0.2b |
| Serum triglyceride level (mM) | 1.6±0.7 | 3.1±1.5a | 2.1±1.4 |
| Serum cholesterol level (mM) | 2.2±0.3 | 3.4±0.8a | 2.4±0.7b |
Data are means±SD (n=8–9). NX=Rats received uninephrectomy, DN=STZ-induced diabetic rat with NX, DN+ASCs=DN rats treated with human adipose-derived stem cells.
a
P<0.05 versus NX group.
b
P<0.05 versus DN group.
ASCs, adipose-derived stem cells; NX, nephrectomy control; DN, diabetic nephropathy.