. Author manuscript; available in PMC: 2013 Dec 9.

Published in final edited form as: J Clin Pharmacol. 2011 Nov 1;52(9):10.1177/0091270011416939. doi: 10.1177/0091270011416939

Table II.

Observed QT Interval Response Associated With Ibutilide in Patients With Heart Failure and in Patients With Normal Left Ventricular Function

Parameter	Heart Failure (n = 6)	Normal Left Ventricular Function (n = 9)	P
Maximum QT_F (leads II, V₁, V₅), s	0.491 (0.482-0.522)	0.495 (0.481-0.527)	.95
Maximum QT_F (lead II), s	0.485 (0.474-0.494)	0.490 (0.481-0.506)	.44
Maximum change in QT_F from pretreatment value (leads II, V₁, V₅), %	17 (17-18)	21 (13-29)	.78
AUEC_0-4, s·h	1.86 (1.86-1.93)	1.82 (1.81-1.84)	.04
AUEC_0-8, s·h	3.67 (3.62-3.79)	3.56 (3.52-3.60)	.04

Data are presented as median (interquartile range). AUEC, area under the effect curve for QT_F interval versus time; QT_F, Fridericia-corrected QT interval.