Table 2. miRNA biogenesis pathway genes and statistical analysis.
The list is compiled by literature review. Roles of the genes in the pathway are annotated in the table. Bonferroni corrected p-values from Students t-test for miRNA biogenesis genes using Rembrandt glioma data is shown. NaN: probeset for gene was not included in microarray.
| Gene Name | Entrez ID | Role in Pathway | Whole Transcriptome Sequencing Dataset P-value (U-test H0: medians are equal) | Rembrandt Glioma Dataset P-value (t-test H0: means are equal) |
|---|---|---|---|---|
| ADAR | 103 | Nuclear Processing | 0.785714 | 1 |
| BMP1 | 649 | Nuclear Processing | 0.035714 | 0.000137 |
| BMP2 | 650 | Nuclear Processing | 0.035714 | 0.007533 |
| DCP1A | 55802 | Cytoplasmic Processing | 0.142857 | 1 |
| DCP2 | 167227 | Cytoplasmic Processing | 0.571429 | 1 |
| DDX17 | 10521 | Nuclear Processing | 0.035714 | 1 |
| DDX20 | 11218 | Cytoplasmic Processing | 0.785714 | 0.00959 |
| DDX5 | 1655 | Nuclear Processing | 0.035714 | 1 |
| DDX6 | 1656 | Cytoplasmic Processing | 0.035714 | 0.000055 |
| DGCR8 | 54487 | Nuclear Processing | 0.571429 | 1 |
| DHX9 | 1660 | Cytoplasmic Processing | 0.071429 | 1 |
| DICER1 | 23405 | Cytoplasmic Processing | 0.142857 | 1 |
| EIF2C1 | 26523 | Cytoplasmic Processing | 0.571429 | 1 |
| EIF2C2 | 27161 | Cytoplasmic Processing | 1 | 1 |
| EIF2C3 | 192669 | Cytoplasmic Processing | 0.392857 | 1 |
| EIF2C4 | 192670 | Cytoplasmic Processing | 0.142857 | 1 |
| GEMIN4 | 50628 | Cytoplasmic Processing | 0.25 | 1 |
| HNRPA1 | 3178 | Nuclear Processing | 0.035714 | 0.002531 |
| MOV10 | 4343 | Cytoplasmic Processing | 0.035714 | 0.000003 |
| PRKRA | 8575 | Cytoplasmic Processing | 0.785714 | NaN |
| PRMT5 | 10419 | Cytoplasmic Processing | 0.142857 | 0.128026 |
| RANGAP1 | 5905 | Transport | 0.25 | 1 |
| RNASEN | 29102 | Nuclear Processing | 0.035714 | 0.000953 |
| SMAD1 | 4086 | Nuclear Processing | 1 | 1 |
| SMAD2 | 4087 | Nuclear Processing | 0.035714 | 1 |
| SMAD3 | 4088 | Nuclear Processing | 0.035714 | 1 |
| SMAD4 | 4089 | Nuclear Processing | 0.035714 | 0.242406 |
| SMAD5 | 4090 | Nuclear Processing | 0.035714 | 1 |
| SMAD6 | 4091 | Nuclear Processing | 1 | 1 |
| SMAD7 | 4092 | Nuclear Processing | 0.035714 | 0.046877 |
| SMAD9 | 4093 | Nuclear Processing | 0.035714 | 0.006042 |
| TARBP2 | 6895 | Cytoplasmic Processing | 1 | 1 |
| TGFB1 | 7040 | Nuclear Processing | 0.142857 | 3.04E-008 |
| TNRC6A | 27327 | Cytoplasmic Processing | 0.321429 | 1 |
| TNRC6B | 23112 | Cytoplasmic Processing | 0.25 | 0.000297 |
| XPO5 | 57510 | Transport | 0.571429 | 1 |