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. 2011 Jul 13;3(3):425–439. doi: 10.3390/pharmaceutics3030425

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 3. — Comparison of (a) Raman spectroscopy (RS) of pure cocaine on a glass slide to (b) SERS for 100 ng/mL (100 ppb) cocaine in water (as cocaine•HCl) using a fused gold colloid-doped sol-gel in a 1 mm capillary. Conditions: (a) 300 mW of 785 nm, 5 minute acquisition, (b) 75 mW of 785 nm excitation, 1 minute acquisition; both at 8 cm⁻¹ resolution. The SERS spectral intensity has been multiplied by 10 so that features are evident, and offset for clarity.