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. 2011 Aug 31;3(3):582–600. doi: 10.3390/pharmaceutics3030582

Figure 3.

Figure 3.

(a) XRPD patterns of the material obtained from using the conveying design at 25, 75, and 90 °C shown in comparison to the physical blend. (b) XRPD patterns of the material obtained from using the mixing design at 25 and 75 °C shown in comparison to the physical blend. New reflection at 13.2° 2θ is marked with an arrow. These data show that mixing in the extruder is essential for cocrystal formation.