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. 2011 Aug 31;3(3):582–600. doi: 10.3390/pharmaceutics3030582

Figure 9.

Figure 9.

(a) XRPD of materials obtained from the TSE of Carbamazepine and Saccharin: A: Physical blend prior to extrusion, B: extrusion at 50 °C, C: Extrusion at 190 °C, D: Extrusion with water at 100 °C, E: Reference Form I cocrystal pattern calculated from the published crystal structure obtained from the Cambridge Structural Database (CSD). (b) DSC thermogram showing comparison of Carbamazepine, Saccharin and the 1:1 Carbamazepine-Saccharin cocrystal. The dotted line in Figure (b) represents the extrusion temperature.