Table 2.
Outcome of TSE experiments performed with Theophylline-Citric acid system.
| Lot# | Component 1 | Component 2 | Type of Extrusion | Temperature | Product |
|---|---|---|---|---|---|
| TC1 | TA | CA | neat | 153 | AC + unreacted* |
| TC2 | TA | CM | neat | 153 | AC + unreacted |
| TC3 | TM | CA | neat | 153 | AC + unreacted |
| TC4 | TA | CM | neat | 50 | AC |
| TC5 | TA | CA | Ethanol-assisted | 20 | AC |
| TC6 | TA | CM | neat | 20 | HC |
| TC7 | TA | CM | Water-assisted | 20 | HC |
TA: Theophylline Anhydrous, TM: Theophylline monohydrate; CA: Citric acid Anhydrous, CM: Citric acid monohydrate; AC: Anhydrous cocrystal, HC: Hydrated cocrystal; * unreacted starting material was observed by XRPD.