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. 2011 Sep 14;3(3):615–635. doi: 10.3390/pharmaceutics3030615

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 7. — (A) Inhibition of ABCG2-mediated MTX transport by gefitinib. Experimental procedures and conditions are described previously [47]. The chemical structure of gefitinib is depicted in this figure. (B) Relationship between observed and predicted values in the inhibition of ABCG2-mediated MTX transport by different test compounds. The inhibition by gefitinib is indicated by an open circle (○). Data are from [47].