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ER stress induces Il1a and Ifnb1 mRNA in BMMo. BMMo derived from WT rats were treated with thapsigargin (TG) (300 ng/ml) for 3 and 6 hours. A, Expression of BiP mRNA relative to untreated cells. B, Xbp1 mRNA splicing. C, D, Expression of Il1a (IL-1α) (C) and Ifnb1 (IFNβ) (D) mRNA relative to untreated cells.
