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. Author manuscript; available in PMC: 2014 Mar 7.
Published in final edited form as: Mol Cell. 2013 Mar 7;49(5):10.1016/j.molcel.2013.01.038. doi: 10.1016/j.molcel.2013.01.038

Figure 2.

Figure 2

Chromatin accessibility at enhancers (A) Cooperative binding of TFs can overcome the nucleosomal barrier and initiate regulatory events on chromatin. (B) Enhancers sites can be made available by the action of “pioneer” factors, which can directly associate with nucleosomal DNA, preceding and commonly also enabling occupancy of other TFs via recruitment of the chromatin remodeling activities. (C) Incorporation of the histone variant H2A.Z, mediated by the TIP60/p400 complex, creates domains of nucleosomal hypermobility that may facilitate initial TF binding events.