Table 1.
Control | RA | LPS | RA + LPS | |
---|---|---|---|---|
BW at dosing, g | 233.8±9.80 | 224.2±8.67 | 212.9±5.74 | 217.9±7.36 |
Change in BW, g/12 h | −6.8±1.0 | −6.4±0.9 | −8.0±1.0 | −8.2±1.0 |
Liver weight, % BW | 3.64±0.06 | 3.76±0.12 | 3.91±0.11 | 4.03±0.10a |
Lung weight, % BW | 0.51±0.02 | 0.53±0.01 | 0.54±0.02 | 0.53±0.02 |
Spleen weight, % BW | 0.22±0.01 | 0.22±0.01 | 0.27±0.01a,b | 0.29±0.01a,b |
Small intestine weight, % BW | 2.29±0.09 | 2.41±0.09 | 2.43±0.13 | 2.43±0.14 |
Plasma retinol, µmol/l | 0.54±0.06 | 0.44±0.06 | 0.30±0.04a,b | 0.29±0.04a,b |
Liver total retinol, nmol/g* | 17±11 | 21±6 | 18±5 | 14±17 |
Total 3H-labeled retinoids, % ID† | 30.0±1.23 | 33.3±1.38 | 26.5±1.16b | 28.1±1.15b |
Values are means ± SE; n = 9/group. RA, retinoic acid; LPS, lipopolysaccharide; BW, body wt.
For liver total retinol, values are means ± range of two representative rats per group.
For total 3H-labeled retinoids, values are sums of plasma, liver, lung, and small intestine total 3H-labeled retinoids, expressed as percent injected dose (ID).
Statistically different from control rats (P < 0.05).
Statistically different from RA-treated rats (P < 0.05).