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. Author manuscript; available in PMC: 2014 Dec 19.
Published in final edited form as: Neuroscience. 2013 Aug 29;254:10.1016/j.neuroscience.2013.08.033. doi: 10.1016/j.neuroscience.2013.08.033

Fig. 6. 3α,5β-THP increases excitability of rat CA1 hippocampal pyramidal cells after a 24 h METH withdrawal.

Fig. 6

A, Representative traces and B, Mean ± SEM, 3α,5β-THP effects on neuronal excitability recorded from CA1 pyramidal cells (rat) in the hippocampal slice using whole cell recordings in current clamp mode. Membrane voltage was assessed in response to 20 pA increases in current injection. A, Red, current threshold (I-threshold) for action potential (AP) generation for the less excitable group (the recording with the higher current threshold: pre-3α,5β-THP or post-3α,5β-THP). Blue, I-threshold for AP generation for the more excitable group (i.e., the recording with the lower current threshold) before or after bath application of 30 nM 3α,5β-THP. Black, trace(s) in-between the two threshold currents. B, 3α,5β-THP increased Rm (ANOVA, F(3,14)=73, P<0.0001) and lowered I-threshold (ANOVA, F(3,14)=22, P<0.0001) only after 24 h METH Wd, an effect reversed by FLU; n=4-5 rats/group. *P<0.0001 vs. all other groups; n=4-5 rats/group.