Table 1.
Summary of the effects of in vivo METH treatments resulting from experiments performed in mice1, rats2 or both* on CA1 hippocampal pyramidal cells. Both α4βδ GABAR expression levels and the polarity of the GABAergic current determine the ultimate effect of 3α,5β-THP on the tonic current and neuronal excitability.
| α4βδ expression in CA1 hippocampus | GABA current | Effect of GABA current* | Effect of 3α,5β-THP on the tonic GABAergic current | Effect of 3α,5β-THP on neuronal excitability | |
|---|---|---|---|---|---|
| CON* | Low | Hyperpolarizing | Inhibitory | Increase | Decrease |
| CHRONIC METH* | High | Depolarizing | Inhibitory | Increase | Decrease |
| METH WD* | High | Hyperpolarizing | Inhibitory | Decrease | Increase |
| METH WD α4−/−1 | None | No effect | |||
| METH WD + FLU2 | Low | Hyperpolarizing | Inhibitory | Increase | Decrease |
*
GABA was inhibitory in all cases regardless of the polarity of the current.