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. Author manuscript; available in PMC: 2014 Dec 19.
Published in final edited form as: Neuroscience. 2013 Aug 29;254:10.1016/j.neuroscience.2013.08.033. doi: 10.1016/j.neuroscience.2013.08.033

Table 1.

Summary of the effects of in vivo METH treatments resulting from experiments performed in mice1, rats2 or both* on CA1 hippocampal pyramidal cells. Both α4βδ GABAR expression levels and the polarity of the GABAergic current determine the ultimate effect of 3α,5β-THP on the tonic current and neuronal excitability.

α4βδ expression in CA1 hippocampus GABA current Effect of GABA current* Effect of 3α,5β-THP on the tonic GABAergic current Effect of 3α,5β-THP on neuronal excitability
CON* Low Hyperpolarizing Inhibitory Increase Decrease
CHRONIC METH* High Depolarizing Inhibitory Increase Decrease
METH WD* High Hyperpolarizing Inhibitory Decrease Increase
METH WD α4−/−1 None No effect
METH WD + FLU2 Low Hyperpolarizing Inhibitory Increase Decrease
*

GABA was inhibitory in all cases regardless of the polarity of the current.