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. 2013 Dec 9;8(12):e77956. doi: 10.1371/journal.pone.0077956

Figure 6. Photoinactivation revealed a direct and specific function of dynamin in actin organization of invadosome.

Figure 6

A–B) Extracted images from time serie (min∶s) from representative observations of DKO-v-Src-MEFs expressing dyn2-KR and GFP-actin. Dynamin photoinactivation leads to a rapid desorganization of actin in invadosome ring and the slow formation of lamellipodia (red arrows) and accumulation of cytosolic actin spots. B) Filopodia (green arrow) and lamellipodia (red arrow) are formed independently of dynamin. Scale bar = 2 µm (A), 4 µm (B, C).