Figure 3. Nifedipine treatment reduces muscle [Ca²⁺]_r in vivo in mdx mice.

Mice were treated with daily intraperitoneal injections of nifedipine 1/Kg for 1-week or saline. A. Experimental setup to measure [Ca²⁺]_r in vivo with Ca²⁺ selective microelectrodes in vastus lateralis muscle. B. Averaged data from [Ca²⁺]_r determinations with or without nifedipine treatment. Data are expressed as mean ± S.E.M. from n fibers in N mice, ***P<0.001, ANOVA-Tukey’s.