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. 2013 Dec 9;8(12):e81364. doi: 10.1371/journal.pone.0081364

Figure 6. Both exercise and PKCβ deficiency reduced high-fat diet-induced mitochondrial dysfunction in the skeletal muscle.

Figure 6

A, Representative images of transmission electronic microscopy (TEM) show mitochondrial abnormality in the skeletal muscle of WT SED mice and reduced mitochondrial damage in the other 3 groups. Note the swollen and decreased matrix density of mitochondrial in WT SED group. Bar: 500 nm; Magnification: 18500×; The arrows indicate mitochondria. B, Mitochondrial number analysis shows that exercise increased mitochondrial number in WT but not in PKCβ-/- mice. Six images per mice, 3 mice per group have been counted and quantified. C, Mitochondrial size analysis shows that mitochondrial size was significantly increased in WT SED group but not in the other 3 groups. Six images per mice, 3 mice per group have been counted and quantified. WT, wild-type; EX, exercise; SED, sedentary; Data are presented as mean ± SEM; *, P<0.05.