Figure 6.

Blockade of Ang-2 signaling ameliorates lung injury in VDR-null mice. WT and KO mice were pretreated with saline or L1–10 for 2 weeks followed by LPS challenge. Lung damage analyses were performed 24 hours after LPS treatment. A, Evans blue permeability assay. B, Total protein concentrations in the BAL. C, MPO activity in total lung lysates. D, IL-6 levels in the BAL fluid. ***, P < .001 vs LPS-treated WT; ##, P < .01; ###, P < .001 vs LPS-treated KO; n = 5–6 in each genotype. Ctrl, control.