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. 2013 Dec 9;8(12):e83191. doi: 10.1371/journal.pone.0083191

Figure 2. Reduced MMC accumulation after Inflammasome activation.

Figure 2

(A) 8-10 week old C57BL/6 mice were infected intravenously with 2.5x104 wt or 1x105 L. monocytogenes L.p.FlaA for 12, 24, and 48 hours. Bacterial CFU from spleen and liver were collected at the indicated time points. Dotted line – limit of detection. The median of four replicates from 4 independent experiments. *P < 0.05 by Mann-Whitney test. (B) LysM+/eGFP mice were infected intravenously with 2.5x104 wt or 1x105 L. monocytogenes L.p.FlaA for 12, 24, and 48 hours. At the indicated time spleens were excised, sectioned, and image using multi-photon microscopy. Multi-photon images of LysM+/eGFP mice at 12, 24, and 48 hours after infection. LysM+/eGFP- green, yellow dotted line-marginal zone, WP-white pulp, RP-red pulp (C) Relative GFP intensity inside individual WP nodule (A.U.). Data representative of 3 independent experiments.