Table 2. Dry weight of iron from the liver and the heart tissues of mice.
Dry weight of Iron (µg/gm)
|
||
---|---|---|
Liver tissue | Heart tissue | |
Normal levels | 101.3 ± 19.1 | 57.2 ± 41.6 |
Iron overloaded mice (Group 1) | 11945 ± 2253 | 389 ± 188 |
Iron overloaded and deferiprone treated mice (Group 2) | 9319 ± 2865 | 138 ± 66* |
Iron overloaded and hydroxyurea treated mice (Group 3) | 10316 ± 2820 | 150 ± 128* |
Iron overloaded and deferasirox treated mice (Group 4) | 11135 ± 1878 | 171 ± 98* |
Iron overloaded and deferiprone and hydroxyurea treated mice (Group 5) | 7136 ± 1631* | 208 ± 200* |
Iron overloaded and hydroxyurea and deferasirox treated mice (Group 6) | 7397 ± 1570* | 159 ± 141* |
Iron overloaded and deferiprone and deferasirox treated mice (Group 7) | 6339 ± 934* | 97 ± 69* |
Iron overloaded and deferiprone, deferasirox and hydroxyurea treated mice (Group 8) | 6739 ± 1764* | 89 ± 60* |
* Statistically significant reduction (p<0.001) in dry weight of liver or heart iron of the particular group compared to the group 1