Table 1. Characteristics of the Study Population Stratified by Natriuretic Peptide Levels.
| Variable | NT-ProBNP | BNP | ||
|---|---|---|---|---|
| ≤ Median (n=1310) |
> Median (n=1309) |
≤ Median (n=1392) |
> Median (n=1227) |
|
| Age (yrs) | 41 (34, 48) | 46 (38, 54)* | 41 (35, 49) | 45 (37, 53)† |
| Male (%) | 58.7 | 30.2* | 51.1 | 37.8† |
| Race (%) | ||||
| Caucasian | 28.2 | 36.2* | 31.5 | 33.0 |
| African-American | 52.1 | 44.1* | 48.1 | 48.0 |
| Hispanic | 16.8 | 18.4 | 18.2 | 17.0 |
| Hypertension (%) | 27.2 | 36.6* | 27.9 | 35.9† |
| Diabetes (%) | 10.5 | 10.5 | 10.7 | 10.3 |
| Hypercholesterolemia (%) | 12.7 | 12.5 | 11.6 | 13.5 |
| Low HDL Cholesterol (%) | 41.7 | 38.4 | 38.7 | 41.4 |
| Metabolic Syndrome (%) | 34.2 | 33.2 | 33.2 | 34.2 |
| Current Smoking (%) | 28.1 | 26.9 | 28.0 | 26.9 |
| Prior CVD (%) | 2.2 | 5.7* | 2.7 | 5.2† |
| Left Ventricular Hypertrophy (%) | 7.4 | 11.9* | 7.4 | 11.9† |
| Weight (kg) | 85.0 (73.0, 99.3) | 78.5 (66.7, 93.0)* | 83.2 (71.4, 98.0) | 80.7 (68.5, 95.3)† |
| Body Mass Index (kg/m2) | 29.5 (25.8, 33.9) | 28.5 (24.5, 33.8)* | 29.3 (25.3, 34.0) | 28.9 (25.1, 33.8) |
| Waist Circumference (cm) | 99.0 (90.0, 110.0) | 95.0 (84.0, 106.0)* | 97.5 (88.0, 109.5) | 96.0 (86.0, 107.5)† |
| Waist/Hip ratio | 0.92 (0.87, 0.98) | 0.88 (0.82, 0.94)* | 0.91 (0.85, 0.97) | 0.89 (0.83, 0.95)† |
| Total Fat Mass (kg) | 24.7 (17.9, 32.2) | 26.1 (19.1, 34.7)* | 24.7 (17.7, 32.5) | 26.1 (19.2, 34.5)† |
| Total Lean Mass (kg) | 58.7 (49.5, 66.6) | 50.0 (43.0, 58.9)* | 56.3 (47.1, 65.3) | 52.4 (44.4, 61.6)† |
| Visceral Fat (kg) | 2.2 (1.6, 2.9) | 1.9 (1.3, 2.6)* | 2.1 (1.5, 2.8) | 1.9 (1.4, 2.6)† |
| Abdominal Subcutaneous Fat (kg) | 4.1 (2.8, 6.1) | 4.4 (2.8, 6.4) | 4.0 (2.8, 6.1) | 4.4 (2.8, 6.4)† |
| Lower Body Fat (kg) | 8.1 (5.8, 11.3) | 9.4 (6.7, 12.6)* | 8.3 (5.8, 11.8) | 9.3 (6.5, 12.4)† |
| Liver Fat (%) | 3.9 (2.3, 7.8) | 3.2 (1.9, 5.6)* | 3.7 (2.2, 7.1) | 3.4 (2.0, 5.9)† |
| LV Ejection Fraction (%) | 72.7 (68.0, 77.1) | 73.6 (68.5, 77.9)* | 73.0 (68.2, 77.3) | 73.3 (68.3, 77.6) |
| LV End-Diastolic Volume/BSA (mL/m2) | 51.0 (45.2, 57.5) | 50.8 (44.5, 58.4) | 51.0 (45.1, 57.5) | 51.1 (44.6, 58.4) |
| LV End-Systolic Volume/BSA (mL/m2) | 14.0 (11.0, 17.2) | 13.3 (10.6, 16.7)* | 13.8 (11.0, 16.8) | 13.7 (10.6, 17.2) |
| Estimated GFR (mL/min per 1.73 m2) | 98.8 (87.1, 112.6) | 95.3 (82.4, 111.2)* | 98.0 (85.4, 112.6) | 96.6 (84.1, 111.4) |
| HOMA-IR | 3.2 (1.8, 5.3) | 2.5 (1.4, 4.4)* | 3.0 (1.7, 5.2) | 2.6 (1.6, 4.6)† |
| Adiponectin (ng/mL) | 5.6 (4.0, 8.2) | 8.0 (5.2, 11.3)* | 5.9 (4.1, 8.8) | 7.5 (4.9, 10.7)* |
| BNP (pg/mL) | 0.0 (0.0, 3.8) | 9.2 (2.4, 22.4) | 0.0 (0.0, 0.5) | 13.0 (6.7, 24.2) |
| NT-proBNP (pg/mL) | 13.2 (5.8, 19.5) | 58.9 (39.8, 99.4) | 16.8 (7.5, 30.3) | 50.6 (25.8, 94.3) |
Data are presented as median (25%, 75% percentile) or proportion (%) where indicated.
Median values for NT-proBNP and BNP are 28.1 and 3.0 pg/mL, respectively.
Abbreviations: BNP= B-type natriuretic peptide; BP= blood pressure; BSA= body surface area; CHD= coronary heart disease; cTnT= cardiac troponin T; CVD= cardiovascular disease; GFR= glomerular filtration rate; HDL= high density lipoprotein; HOMA-IR= homeostasis model assessment of insulin resistance; LV= left ventricular
*
p<0.05 vs. ≤ Median NT-proBNP group
†
p<0.05 vs. ≤ Median BNP group