Figure 3.

Regulation of integrin-mediated responses by ECM substrates. Binding of ECM proteins to the alpha-subunit of integrins triggers a variety of processes that involve formation of multiprotein complexes. Integrins that are activated by the ECM substrates bind to a variety of cytosolic scaffold and signaling proteins, including ILK, FAK, and vinculin. ILK can bind to paxillin, to PINCH and/or parvins, which then modulate F-actin polymerization and remodeling, regulating cell adhesion to the ECM and/or migration. ECM, extracellular matrix; FAK, focal adhesion kinase. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/wound