Table 1.
Phenotypic features of different tumor-infiltrating myeloid cell populations.
| Cell type | Other names | Surface markers | Chemokine receptors | Phenotype | Human tumors observed within | Reference |
|---|---|---|---|---|---|---|
| MDSC | CD11b+GR-1+ (m), Lin-CD33+MHC-II−or CD11b+CD33+CD14−(h) | Immunosuppressive | Breast, renal-cell, pancreatic, melanoma, head and neck | Gabrilovich and Nagaraj (9) | ||
| Mature DC | Classical DC | CD11c+MHC-IIhigh | CCR7, CXCR4 | Immunostimulatory | ||
| Immature DC | CD11c+MHC-IIlow | CCR6, CCR2, CXCR4 | Antigen uptake, Immunosuppression | Ovarian, breast, lung, colorectal, melanoma, renal-cell, prostate | Chaux et al. (10), Pinzon-Charry et al. (11), Perrot et al. (12) | |
| Pre-DC | CD11c+MHC-II− | CCR1, CCR5, CCR2 | Committed to DC lineage | |||
| Regulatory DC | Tolerogenic DC | CD11c+CD11b±, MHC-II+CD86highPD-L1+ | CXCR4, CCR6 | Immunosuppressive | Cervical, hepatocellular, breast, ovarian | Lee et al. (13), Ormandy et al. (14), Pinzon-Charry et al.(15), Scarlett et al. (16) |
Mouse and human markers are indicated by (m) and (h), respectively.