Figure 7.

Intravenous injection of miR-29s inhibits leukemic spreading in AML model mice. (a) Diagram illustrating the experimental design in NOD/SCID mice. (b and c) Percentage of human CD33+ cells engrafted in the murine BM and spleen was determined by FACS. The results of three mice from each group were shown. (d) Measurement of spleen size in mice. Representative of the spleen of one mouse obtained from each group (upper). Statistic analysis of spleen size among different group (lower): untreated (n=3), con (n=5), 29a (n=5), 29b (n=5), 29c (n=5). Untreated and con: ***P<0.0001; con and 29a: ***P<0.001; con and 29b: *P<0.05; con and 29c: ***P<0.0001