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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Fertil Steril. 2013 Jan;99(1):10.1016/j.fertnstert.2012.11.039. doi: 10.1016/j.fertnstert.2012.11.039

FIGURE 1.

FIGURE 1

Schematic diagram of telomere loop (T loop) and shelterin proteins. Telomere repeat-binding factor 1 and 2 (TRF1, TRF2) associate with double-stranded DNA and serve as binding substrate for TIN2, TPP1, and Rap1. A third DNA-binding protein, Pot1, associates with the single-stranded DNA of the displacement loop (D loop).

Kalmbach. Telomeres and human reproduction. Fertil Steril 2013.