Figure 1.

Expression levels of selected genes with damaging de novo mutations in dorsolateral prefrontal cortex throughout development (8 post-conception weeks to 40 years). Many network genes were highly expressed during early fetal prefrontal cortical development, with expression declining in late fetal development and childhood, and rising again during adulthood, coinciding with the typical age of onset of schizophrenia. Data were obtained from BrainSpan: Atlas of the Developing Human Brain (2013). RPKM values were max-min normalized and Loess smoothed across time points.